A personal and primarily local look back at the year. What are the major infectious diseases events in modern Singapore in 2017? Outbreaks The World Health Organization (WHO) has a list of outbreaks by year on its website, and the 2017 list is depressingly long. There are the usual “suspects” like cholera (Africa) and diphtheria […]

I was directed to this recently published Science article by a Lee Kong Chian School of Medicine clinician-scientist while we were discussing the Dengvaxia debacle. As highlighted in a previous post, Sanofi Pasteur had reported that dengue-naive people would be at higher risk of a more severe infection if they were infected with dengue following vaccination […]

Sanofi-Pasteur released a media report on 29 November, warning that dengue-naive people would be at higher risk of a more severe infection if they were infected with dengue following vaccination with Dengvaxia – Sanofi Pasteur’s dengue vaccine that is also licensed for use in Singapore. This warning was based on the analysis of 6 years […]

Dengvaxia (CYD-TDV) – the first licensed dengue vaccine – is a quadrivalent live attenuated chimeric dengue vaccine developed by Sanofi Pasteur. An attenuated yellow fever virus forms the backbone of the vaccine, with dengue structural proteins attached (the chimera). It has just been licensed in Singapore, and is approved for use in those between the ages […]