There are a series of clinical trials published this year that challenge long-held notions in the treatment of infectious diseases. When I was a trainee, we routinely prescribe high-dose intravenous antibiotics for prolonged periods of 4 to 6 weeks for infective endocarditis (infection of the heart valves), because the conventional understanding was that high concentrations […]

Dr. Kathryn Holt from the University of Melbourne published a very important paper in the Proceedings of the National Academy of Sciences yesterday, using whole genome sequencing to study the population structure as well as virulence and antimicrobial resistance factors of Klebsiella pneumoniae. A total of 288 isolates from 6 countries (Australia, Indonesia, Laos, Singapore,  U.S.A. […]

The idea for this post arose from discussions and tutorials with local ID trainees, all (at least those I have contact with) of whom routinely send patients with community-acquired Klebsiella pneumoniae bacteraemia for eye screening by an ophthalmologist to “exclude endophthalmitis”, and some who apply the same practice even to patients with hospital-acquired Klebsiella pneumoniae bacteraemia. Endogenous endophthalmitis occurs as a result […]