There are a series of clinical trials published this year that challenge long-held notions in the treatment of infectious diseases. When I was a trainee, we routinely prescribe high-dose intravenous antibiotics for prolonged periods of 4 to 6 weeks for infective endocarditis (infection of the heart valves), because the conventional understanding was that high concentrations […]

An elderly man presented with fever and malaise for a week followed by right buttock pain which was worse on sitting for 2 days. He has well-controlled hypertension and ischemic heart disease. An X-ray of the lumbosacral spine showed narrowing of the L2-L3 disc space following which an MRI of the spine was arranged. Blood […]

A 3-year-old boy presented with mild left foot pain 6 weeks ago, which resulted in limping 3 weeks ago, followed by swelling over the dorsum of the foot less than a week ago. He was previously healthy except for perianal abscess which developed 1 week after birth.He had met (and exceeded several of) his development […]

A middle-aged man presented with a low-grade fever (37.8 degrees Celsius) and sudden pain over his right thigh for 3 days, which did not resolve with painkillers. He has a history of diabetes mellitus, and had a road traffic accident 30 years ago resulting in the fracture of his right femur. This was repaired (open reduction […]