I received the Ministry of Health Clinical Practice Guidelines (CPG) for tuberculosis a couple of weeks ago. The full version is also available on the MOH website here. Mixed feelings. There is always a bit of pride at having contributed to such things. Having sat in on the meetings, I am also aware of the […]

The first case of imported Zika infection in Singapore was announced on the mainstream media yesterday – a Singaporean permanent resident who had traveled to Sao Paulo, Brazil between 27th March and 7th May and who had developed symptoms on 10th May. According to the news report, he is recovering (Zika causes mild disease in […]

It has been more than two weeks since the story first broke on mainstream media. More than a hundred additional cases have been linked to the durian pastry outbreak (bringing the total to at least 183 cases), while the Goodwood Park Hotel bakery remains suspended. The initial investigation was reportedly performed from 4th April (i.e. […]

Wrote a piece on Zika thanks to a kind invitation from the SMA News Editor. Submitted 9th March, published a few days ago, and already largely out of date. We have to accept that this is the speed of information gain today, which in many ways is not a bad thing. It is now widely […]

The other piece of infectious disease-related news in the Straits Times today was on parechovirus infections. In an (as far as I can tell) unpublished study, follow-up of 80 babies infected with human parechovirus (HPeV) type 3 in Sydney showed that developmental delays had occurred in more than half of them after a year. About a […]

In the first large foodbourne outbreak of the year (to my knowledge anyway), seventy-six cases of food poisoning so far have been linked to the consumption of durian pastries from Goodwood Park Hotel according to various mainstream news reports today, resulting in the suspension of the hotel bakery’s food establishment license by the National Environment […]

In the previous post, we discussed the situation where the fever has resolved. How long should antibiotics be continued? If the cultures are negative, antibiotics can be stopped immediately with neutrophil recovery (the situation where neutropenia remains persistent is controversial and was also discussed previously). There is a tendency locally to continue intravenous antibiotics for […]

Back to the febrile neutropenia management series. Two questions frequently arise during the course of management, particularly with regards to febrile neutropenia (FN) in patients with haematological malignancies where the duration of neutropenia may be very long: In the presence of neutropenia, can there be “de-escalation” of antibiotic therapy if a sensitive bacterium is cultured […]

Almost two weeks ago, Channel News Asia reported that terrapins may harbour non-typhoidal Salmonella bacteria. Non-typhoidal Salmonella, as the term suggests, are Salmonella species other than the exclusively human-adapted Salmonella spp. that cause enteric (i.e. typhoid and paratyphoid) fever. The former tend to cause gastroenteritis for the large part, although they may also cause severe infections in immunocompromised persons, including […]

Interrupting the febrile neutropenia series to write about Zika virus, which has been in the global news for some months but very recently became a hot topic in the local mainstream news because of the explosive nature of its spread in South America, the new association of this South American strain with microcephaly (in children […]