Methicillin-resistant Staphylococcus aureus (MRSA) probably emerged in Singaporean hospitals in the 1970’s. The exact date, and whether the first isolates were imported from overseas or arose from within Singapore’s own S. aureus population is no longer known (or at least I have not been able to find someone who has a clear recollection of these events). We do have some evidence that it had become a significant problem in the hospital by the late 1970’s – there’s a snapshot of the annual bacterial susceptibility testing report from one of Singapore’s hospitals in 1979, showing that almost 19% of S. aureus isolated that year were methicillin-resistant (on a separate note, the antibiotics on the panel may also be of some historical interest – it is sobering to note that many of the antibiotics we take for granted today, like ceftriaxone, carbapenems, and the fluoroquinolones, were not available then!).


Annual antibiogram extracted from a local hospital’s report, 1979.

Separate corroboration can be in a paper published in 1986 by Prof Warren Grubb (Perth, Australia) and Dr Tay Leng (Singapore General Hospital, Singapore) in the European Journal of Clinical Microbiology. The authors stated that MRSA rates in Singapore General Hospital had increased from 12% of all S. aureus clinical isolates in 1982 (a lower figure than in the 1979 report) to 16% in 1983 and 27% in 1986. Although the initial speculation was that the MRSA in Singapore could have come from Australia in view of the “large tourist trade”, this was not borne out on molecular analysis of the Singapore isolates. It’s not easy to access this old paper, hence I have taken the liberty of providing it below.

Eur. J. Clin. Microbiol. 1986 Grubb

It wasn’t until the early 1990’s that MRSA became a public concern in Singapore, however. It is clear that alarms had been sounded within the healthcare system itself – in the February 1991 issue of the Singapore Medical Journal, both Dr David Allen (an infectious diseases physician brought in to develop the infectious diseases medical specialty in Singapore) and Dr Mavis Yeo (a microbiologist) had highlighted their concerns with MRSA spreading in Singapore’s hospitals. In 1993, for the first time, a report of the MRSA outbreak at the Singapore General Hospital made it to the Straits Times (22nd February 1993), stating that “21 died from infection picked up in hospital”. In a follow-on article on 27th February 1993, it was reported that “people had checked out and cancelled operations overnight”. And in a forum letter in March 1993, a non-medical person had castigated the local authorities and the healthcare system (“S’poreans must assert rights on health matters” 25th March 1993), stating among other things:

  • “Not wanting to cause public alarm is not an acceptable excuse for keeping people in the dark and for not taking preventive measures.”
  • “A hush-up approach does little to instil public confidence in the health care system and the medical profession.”
  • “An apathetic public, a conservative medical profession and health bureaucrats who are reactive rather than pro-active are the perfect ingredients for medical disasters.”

Truly hard-hitting! It is my personal belief that this series of press reports and forum letters, directly or indirectly, in addition to the pressure exerted by concerned clinicians, resulted in the implementation of the first major MRSA campaign in Singapore hospitals.

I will discuss this first major MRSA campaign – which I consider a decided failure – in a separate post (at some later date!). But I will leave one final chart below, showing MRSA “publications” in the non-medical press in Singapore by year, from 1990 to 2009. Unfortunately, it is incomplete in that I have not been able to include media reports in languages other than English…

MRSA in the local news (and parliamentary reports)

MRSA in the local news (and parliamentary reports)

Join the conversation! 4 Comments

  1. […] promised in an earlier post to discuss what I felt was the first major anti-MRSA campaign in Singapore. Although it occurred […]


  2. […] at this time (2006-2007)? I don’t have the answer, but the following chart from a previous post – now annotated – shows an intriguing association. Each of the two MRSA […]


  3. […] in the 1980’s for typing. This collaboration did result in an academic publication, and I had documented it in an earlier post, along with the actual paper itself. Another stroke of luck occurred in the late 1990’s. One of the laboratory technologists […]



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MRSA, Singapore


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